منابع مشابه
Until proven otherwise, 5% spinal procaine is not neurotoxic.
To the Editor:—We read with interest the article by Johnson and Swanson on procaine neurotoxicity, and are interested in why they decided to use undiluted 10% procaine instead of 5% procaine prepared with 10% procaine and equal volumes of either 10% glucose or cerebral spinal fluid. When the first report of transient radicular irritation with spinal anesthesia using 5% lidocaine appeared, our d...
متن کاملComparative spinal neurotoxicity of prilocaine and lidocaine.
BACKGROUND Reports of major and minor sequelae following lidocaine spinal anesthesia have generated interest in an alternative short-acting intrathecal agent. Of the available anesthetics suitable for short-duration spinal anesthesia, prilocaine is perhaps the most promising agent. However, data comparing the neurotoxicity of these agents are lacking. Accordingly, the present experiments invest...
متن کاملNeurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine
Local anaesthetics (LAs) may lead to neurological complications, but the underlying mechanism is still unclear. Many neurotoxicity research studies have examined different LAs, but none have comprehensively explored the distinct mechanisms of neurotoxicity caused by amide- (bupivacaine) and ester- (procaine) type LAs. Here, based on a CCK8 assay, LDH assay, Rhod-2-AM and JC-1 staining, 2',7'-di...
متن کاملWhy was 10% procaine used?
To the Editor:—We read with interest the article by Johnson and Swanson on procaine neurotoxicity, and are interested in why they decided to use undiluted 10% procaine instead of 5% procaine prepared with 10% procaine and equal volumes of either 10% glucose or cerebral spinal fluid. When the first report of transient radicular irritation with spinal anesthesia using 5% lidocaine appeared, our d...
متن کاملWhen the model does not fit the data, the model is wrong.
In Reply:—We appreciate the comments of Drs. Shulman and Robelen, and of Dr. Kitagawa, in emphasizing the potential for neurotoxicity of undiluted 10% procaine in spinal anesthesia, consistent with our case report. We also appreciate the correspondents including references to the work of Watkins and colleagues from early publications which have not been included in modern medical indices, as th...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2008
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e31817fdeb8